New Research on Terpene and Cannabinoid Interaction

New Research on Terpene and Cannabinoid Interaction

Pharmacy researchers in Romani at the Ovidus University of Constanța and the University of Medicine, Pharmacy Science and Technology of Târgu Mures believe the interaction between phytocannabinoids and biological systems, especially the endocannabinoid system, needs further study. The researchers hope more research could lead to novel treatments and expansion of the field of cannabinoid-based medicine. The project, reported in the International Journal of Molecular Science, explores what is known today about cannabinoids and their potential for therapeutic use.

While CBD and THC have been the primary focus of research, the potential of other cannabinoids, such as CBC, CBD, and CBN, is also being explored. These lesser-studied compounds could offer unique pharmacological effects, indicating the need for more comprehensive research on the therapeutic value of phytocannabinoids.

One of the pivotal discussions revolved around the entourage effect, a phenomenon where the interaction of the cannabinoids and terpenes produces a more potent and diverse range of effects compared to their individual contributions. This synergy underscores the crucial need to view the cannabis plant as a whole, rather than focusing solely on individual cannabinoids. A growing new research area concerns the entourage effect. Cannabinoids, terpenes, flavonoids and other plant molecules may work together to deliver potentially powerful interactions. A new cannabis compound, flavorants, was discovered last year, too, which are believed to contribute to the unique smells of the marijuana plant.

The report discusses what research studies have found to date concerning the effects of THC, CBD, CBG, CBC, CBN and THV-C. For example, THC has demonstrated analgesic and antiemetic effects. CBD has been shown to have analgesic and neuroprotective qualities and may help with discomfort. Preliminary research also indicates that CBD may help with alcohol and opioid withdrawal systems. Both CBD and THC have been investigated as sleep aids. CBG and CBN seem to have antibacterial effects, while CBN may be useful as sleep supporter. THC-V may work to suppress appetite.

Researchers noted that social and legal obstacles are stymying research on cannabinoids like CBD despite not being psychoactive. They wrote,

“Despite its potential, legal restrictions and societal stigma surrounding cannabis hinder investment in research and development. Complex regulatory frameworks further complicate exploration efforts. Rigorous preclinical and clinical trials are imperative to establish safety and efficacy before therapeutic implementation.”

It is unfortunate that cannabinoid-based potentially therapeutic novel medical treatments for various common issues are not being investigated to a greater degree. Perhaps that will change as the research continues to show that cannabinoids may have proven potential as natural plant-based compounds delivering health benefits and the power of the entourage effect to address various wellness issues.


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