Research Review Finds High Doses of CBD Are Safe

  • Updated December 1, 2022

  • Published December 1, 2022

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Research Review Finds High Doses of CBD Are Safe

Scientists at the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney, Australia reviewed scientific literature reporting on the efficacy and safety of oral CBD products. The reviews were limited to research studies in which people took daily CBD doses of no more than 400 mg. This dosage is considered a significant CBD dosage.

The scientists reviewed 29 double-blind, placebo-controlled clinical trials and six open-label studies investigating low oral doses of CBD. A double-blind study is one in which the researchers and the participants do not know who is taking the placebo versus taking the intervention. In this case, the intervention is CBD.

There is a two-part finding as a result of the literature review. First, the scientists concluded that CBD “appears exceptionally safe” at doses as high as 6000 mg or 1500 mg CBD administered in more than one dose. Any side effects reported were minor, and the reported side effects were in studies that were not placebo-controlled. This means there is no assurance that the side effects were due to CBD.

“Few adverse events were reported in any of the studies considered, even at the 300–400 mg dose range where efficacy was most often reported,” read the final report.

The second finding was that there is limited reliable evidence for CBD efficacy at lower doses of 400 mg or less. The more the dosage was increased, the more some effects were experienced. Efficacy, or the desired result, was most apparent in people taking CBD doses of 300-400 mg. The review by the scientists focused on five psychological and physical conditions. The conditions included persistent discomfort, and more.

Research like this is necessary because it brings together diverse clinical studies. A clinical trial that stands alone may produce results, but accumulating the results of multiple studies presents a larger and more reliable picture. Future high-quality clinical trials are needed to learn more about the potential therapeutic impacts of CBD doses in a certain amount, especially at lower doses. In addition, as the scientists suggested, additional research could lead to improvements in CBD.


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